Prepulse Inhibition of Acoustic Startle Reflex as a Function of the Frequency Difference between Prepulse and Background Sounds in Mice
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Prepulse Inhibition of Acoustic Startle Reflex as a Function of the Frequency Difference between Prepulse and Background Sounds in Mice
BACKGROUND Prepulse inhibition (PPI) depicts the effects of a weak sound preceding strong acoustic stimulus on acoustic startle response (ASR). Previous studies suggest that PPI is influenced by physical parameters of prepulse sound such as intensity and preceding time. The present study characterizes the impact of prepulse tone frequency on PPI. METHODS Seven female C57BL mice were used in t...
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s | 57 in mPFC and DA efflux in dSTR. NGB and Blo improved the scPCP-induced NOR deficit. The combination of SED NGB and Blon improved the NOR deficit. Conclusions: D3 receptor blockade may contribute to the ability of Blon to increase cortical ACh and DA efflux, as well as to restore NOR in scPCP deficit. D3 receptor blockade may be an important component of the efficacy of Blon to enhance neu...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0045123